Search Result

Search Results for " il 23 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T22338	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide	GDC046	Others , JAK
	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.		Others , JAK
T38362	Guselkumab	CNTO 1959	IL Receptor
	Guselkumab (CNTO 1959) is a recombinant human IgG1 monoclonal antibody targeting the IL-23p19 subunit. Guselkumab binds to human cynomolgus monkey IL-23 with Kd values of 3.3 and 1.9 pmol/L, respectively. Guselkumab can ...		IL Receptor
T76778	Risankizumab	Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066	IL Receptor
	Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. Risankizumab inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM.R...		IL Receptor
T9913	Ustekinumab		Interleukin
	Ustekinumab is an anti-IL-12/IL-23 IgG1κ human monoclonal antibody.		Interleukin
T3533	Apilimod mesylate	STA 5326 mesylate	IL Receptor , PI3K , Interleukin
	Apilimod mesylate (STA 5326 mesylate) is a potent IL-12/IL-23 inhibitor.		IL Receptor , PI3K , Interleukin
T76784	Tildrakizumab	MK 3222,SCH 900222	IL Receptor
	Tildrakizumab (SCH 900222) is a potent humanized monoclonal antibody against IL-23 (p19 subunit). Tildrakizumab targets single-stranded IL-23 with a Kd value of 136 pM. Tildrakizumab can be used to study psoriasis and ps...		IL Receptor
T2018	Apilimod	STA 5326	IL Receptor , PI3K , Interleukin
	Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.		IL Receptor , PI3K , Interleukin
T28958	TG6-129	TG6 129	Prostaglandin Receptor
	TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and...		Prostaglandin Receptor
T14687	Deucravacitinib	BMS-986165	Tyrosine Kinases , JAK , IFNAR , Interleukin
	Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively bi...		Tyrosine Kinases , JAK , IFNAR , Interleukin
T2061	APY0201		PI3K , Interleukin
	APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3, 5)P2.		PI3K , Interleukin
T76934	Brazikumab
	Brazikumab (AMG 139), a human IgG2 monoclonal antibody, selectively targets the p19 subunit of IL-23 with a dissociation constant (K D) of 0.138 nM, indicating high affinity for human IL-23. It is employed in Crohn's dis...
T13232	TyK2-IN-2		PDE
	TyK2-IN-2 is a selective inhibitor of TYK2 (IC50s: 7 nM, 0.1 μM, and 0.05 μM for TYK2 JH2, IL-23, and IFNα).		PDE
T70394	Deucravacitinib HCl
	Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bo...
T70214	BMS-986202
	BMS-986202 is a novel Tyk2 inhibitor, binding to Tyk2 JH2, showing efficacies for IL-23-driven acanthosis, anti-CD40-induced colitis, and spontaneous lupus.
T10210	A-9758		ROR
	A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 s...		ROR
T76935	Briakinumab
	Briakinumab (ABT-874), a fully human anti-IL-12/23p40 monoclonal antibody, selectively targets and neutralizes IL-12 and IL-23. This compound is utilized in the research of various autoimmune disorders, including rheumat...
T81668	NLRP3 agonist 1		NOD-like Receptor (NLR)
	NLRP3 agonist 1 (compound 23) serves as a potent, orally active agent that activates Caspase-1 enzyme, leading to the cleavage of proinflammatory cytokines pro-IL-1β and pro-IL-18 into their active forms [1].		NOD-like Receptor (NLR)
T75094	STING agonist-26
	STING agonist-23 (CF508), a non-nucleotide small-molecule STING agonist, activates STING, thereby enhancing the phosphorylation of STING, TBK1, and IRF3. This activation elevates the production of IFN-β, IL-6, CXCL-10, T...
TP1978	11R-VIVIT	NFAT inhibitor, Cell Permeable
	NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated ...
T75091	STING agonist-23
	STING agonist-23 (CF502) is a non-nucleotide, small-molecule stimulator of the STING pathway. Upon activation, it enhances the phosphorylation of STING, TBK1, and IRF3, leading to elevated levels of IFN-β, IL-6, CXCL-10,...
T75093	STING agonist-25
	STING agonist-23 (CF505) is a non-nucleotide, small-molecule compound that stimulates STING, enhancing the phosphorylation of STING, TBK1, and IRF3. It elevates the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and ...
T75096	STING agonist-28
	STING agonist-23 (CF510) is a non-nucleotide, small-molecule activator of the STING pathway. It initiates the phosphorylation of STING, TBK1, and IRF3, enhancing the production of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and...
T75092	STING agonist-24
	STING agonist-24 (CF504), a non-nucleotide small-molecule STING agonist, activates STING, leading to increased phosphorylation of STING, TBK1, and IRF3. It elevates levels of IFN-β, IL-6, CXCL-10, TNF-α, ISG-15, and CCL-...
T63558	IRAK4-IN-21
	IRAK4-IN-21 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 5 nM) and TAK1 (IC50: 56 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.17 μM. can be ...
T63559	IRAK4-IN-22
	IRAK4-IN-22 is a selective, orally active, potent IRAK4 inhibitor that acts on IRAK4 (IC50: 3 nM) and TAK1 (IC50: 17 nM). IRAK4-IN-21 exhibits potent inhibition of IL-23 production with an IC50 value of 0.10 μM. IRAK4-IN...
T68485	Apilimod HCl
	Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits c...
T6404	Bazedoxifene hydrochloride	Bazedoxifene HCl,TSE-424	Estrogen Receptor/ERR , Estrogen/progestogen Receptor
	Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM and 89 nM, respectively.		Estrogen Receptor/ERR , Estrogen/progestogen Receptor

Compounds

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

Synonym: Risankizumab rzaa,SKYRIZI,ABBV 066,BI-655066

Synonym: STA 5326 mesylate

Target: IL Receptor, PI3K, Interleukin

Tildrakizumab

T76784

Synonym: MK 3222,SCH 900222

Target: IL Receptor, PI3K, Interleukin

TG6-129

T28958

Synonym: TG6 129

Target: Prostaglandin Receptor

Deucravacitinib

T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

APY0201

T2061

Synonym:

Target: PI3K, Interleukin

Target: NOD-like Receptor (NLR)

Synonym: NFAT inhibitor, Cell Permeable

Bazedoxifene hydrochloride

T6404

Synonym: Bazedoxifene HCl,TSE-424

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor

Cat No.	Product Name	Synonyms	Targets
TN6722	Terminolic acid	2α,6β,23-trihydroxyl oleanolic acid	Antibacterial
	Terminolic acid (2α,6β,23-trihydroxyl oleanolic acid) is a pentacyclic triterpenoid glucoside isolated from Combretum racemosum, can inhibit the pro-inflammatory cytokines by binding to receptor active site of IL-1β and ...		Antibacterial

Natural Products

Terminolic acid

TN6722

Synonym: 2α,6β,23-trihydroxyl oleanolic acid

Target: Antibacterial

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00406	IL-23 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-03526	IL-23 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.3 kDa and the accession number is Q9EQ14&P43432.
TMPY-05247	IL-23 Protein, Human, Recombinant (His), Biotinylated	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 55.8 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-04874	IL-23 P19/IL23A Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9NPF7.
TMPY-05648	IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	IL-23 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 57.6 kDa and the accession number is NP_002178.2&NP_057668.1.
TMPY-03490	IL-22 Protein, Human, Recombinant	Human	E. coli
	IL-22 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.9 kDa and the accession number is A0A7R8C389.
TMPY-04987	IL-23 P19/IL23A Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	IL-23 P19/IL23A Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 45 kDa and the accession number is Q9NPF7.
TMPK-01169	IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293 Cells
	The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells...
TMPY-00754	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99)	Human	HEK293 Cells
	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99) is expressed in HEK293 mammalian cells. The predicted molecular weight is 8 kDa and the accession number is A0A024RDA5.
TMPJ-00351	IL-23R Protein, Human, Recombinant (aa 24-353, hFc)	Human	HEK293 Cells
	Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-...
TMPK-00652	IL-23R Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	IL-23R Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.03 kDa and the accession number is G7NWY5.
TMPK-00353	IL-23R Protein, Human, Recombinant (aa 24-355, His)	Human	HEK293 Cells
	IL-23R Protein, Human, Recombinant (aa 24-355, His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.15 kDa and the accession number is Q5VWK5-1.
TMPK-00575	IL-23R Protein, Canine, Recombinant (His)	Canine	HEK293 Cells
	IL-23R Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 39.31 kDa and the accession number is A0A8I3PXL0.
TMPK-01094	IL-23R Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	IL-23R Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 41.48 kDa and the accession number is Q8K4B4.
TMPJ-01219	IL-23R Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several ...
TMPY-04973	IL-22 Protein, Human, Recombinant (His)	Human	P. pastoris (Yeast)
	IL-22 Protein, Human, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 18.1 kDa and the accession number is A0A7R8C389.
TMPK-00661	IL-22 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab...
TMPY-03689	IL-23 Protein, Marmoset, Recombinant (His)	Marmoset	HEK293 Cells
	IL-23 Protein, Marmoset, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.10 kDa.
TMPK-01194	IL-22 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	E. coli
	The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeab...
TMPY-04792	IL-23 Protein, Rabbit, Recombinant (His)	Rabbit	HEK293 Cells
	IL-23 Protein, Rabbit, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 56.6 kDa and the accession number is XP_002710393.1&XP_002711125.1.
TMPY-02494	IL-23 Protein, Rat, Recombinant (His)	Rat	HEK293 Cells
	IL-23 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.2 kDa and the accession number is NP_569094.1&EDM04146.1.
TMPY-00468	IL-23 Protein, Human, Mouse, Recombinant (His)	Human,Mouse	HEK293 Cells
	IL-23 Protein, Human, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.3 kDa and the accession number is Q9NPF7&P43432.
TMPY-00753	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99, hFc)	Human	HEK293 Cells
	IL-8/CXCL8 Protein, Human, Recombinant (aa 23-99, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 35.6 kDa and the accession number is A0A024RDA5.
TMPH-00779	IL-23 P19/IL23A Protein, Guinea Pig, Recombinant (His & Myc)	Guinea pig	E. coli
	Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 b...
TMPK-01378	IL-12B Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Interleukin (IL)‑12B, which encodes the p40 subunit common to IL‑12 and IL‑23, as one of the genes for which expression in fibroblast‑like synoviocytes from patients with rheumatoid arthritis (RA‑FLS) is induced by DcR3....
TMPJ-00047	IL-31 Protein, Human, Recombinant	Human	E. coli
	Human Interleukin 31 (IL-31) is a cytokine containing a four-helix bundle structure. It shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. Human IL-31 cDNA encodes...